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CRH itself provides negative feedback regulation of this process.
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![membrane gates s s s s s s s s ss membrane gates s s s s s s s s ss](https://media.springernature.com/lw685/springer-static/image/art%3A10.1007%2Fs41048-018-0074-y/MediaObjects/41048_2018_74_Fig2_HTML.png)
Combined opto- and chemo-genetic manipulations along with multisite extracellular recordings in urethane anaesthetised CRH Cre mice show that Barr CRH neurons provide a probabilistic drive that generates co-ordinated voids or non-voiding contractions depending on the phase of the micturition cycle. Barr CRH neurons can generate bladder contractions, but it is unknown whether they act as a simple switch or provide a high-fidelity pre-parasympathetic motor drive and whether their activation can actually trigger voids. Ponto-spinal glutamatergic neurons that express corticotrophin-releasing hormone (CRH) form one of the largest Barr cell populations. This involves a spino-bulbospinal control circuit incorporating Barrington’s nucleus in the pons (Barr). Micturition requires precise control of bladder and urethral sphincter via parasympathetic, sympathetic and somatic motoneurons.
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